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Depletion of tumor associated macrophages by anti-BAG3 treatment complements PD-1 blockade in pancreatic cancer

   
@article{APC4543,
	author = {Yi Sun and Robert J. Torphy and Yuwen Zhu},
	title = {Depletion of tumor associated macrophages by anti-BAG3 treatment complements PD-1 blockade in pancreatic cancer},
	journal = {Annals of Pancreatic Cancer},
	volume = {1},
	number = {6},
	year = {2018},
	keywords = {},
	abstract = {New literature published in Gut has shown that combined treatment of anti-BAG3 mAb and anti-PD-1 mAb in pancreatic cancer can eliminate tumor-associated macrophages (TAMs), increase tumor infiltrating CD8+ T cells and result in tumor growth suppression (1). These findings highlight the potential of BAG3 (Bcl-2-associated athanogene 3) as a therapeutic target in conjunction with immune checkpoint blockade in the treatment of pancreatic cancer.},
	issn = {2616-2741},	url = {https://apc.amegroups.org/article/view/4543}
}