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Reviewer of the Month (2025)

In 2025, APC reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Annals of Pancreatic Cancer 2023 CiteScore Released: 0.9

We are pleased to announce that the Annals of Pancreatic Cancer (APC) has received its 2023 CiteScore: 0.9, ranking 124 out of 167 journals in the Internal Medicine category.

Furthermore, we are delighted to highlight the remarkable achievements made by all AME journals in the CiteScore ranking.

Genetic alterations in the neuronal development genes are associated with changes of the tumor immune microenvironment in pancreatic cancer

Except for PTPRM and NBEA, genetic alterations involving these 20 genes are associated with significant changes in the densities of major immune cell subtypes. Except for AJAP1, the copy number loss involving this panel of neuronal development genes is significantly associated with changes in immune cell infiltrates. In contrast, the copy number gain in fewer genes, including NRXN3, ZNF667, ACSM3, C6, ADCY5, SCN9A, and PRKCE, is significantly associated with changes in immune cell infiltrates.

Painful tongue lesion as an initial presentation of metastatic pancreatic ductal adenocarcinoma: a case report and review of the literature

This report presents a unique case of a 91-year-old man who initially presented with a painful tongue mass and ultimately was found to have metastatic pancreatic ductal adenocarcinoma. Comparison of a biopsy from the tongue mass and the pancreatic lesion showed they were morphologically identical and confirmed the diagnosis. Treatment of the tongue lesion with palliative radiation led to clinical improvement of difficulty and pain with swallowing.

Association of a genetic variant in the adenosine triphosphate transmembrane glycoprotein and risk of pancreatic cancer

In the current study, there was no significant difference between rs1045642 and sufentanil consumption (P>0.05), while previous investigation showed a positive association between the variation and PC. Pang et al., in 2014, investigated the potential relationship between the progression of PC and chemical resistance. In this study, 4 SNPs in different genes, including ABCB1, and the expression of 3 transporters were investigated in healthy and cancerous samples.

Why do we need a journal solely focused on the malignant diseases of the pancreas?

Pancreatic cancer has become the third leading cause of death from malignant diseases in both the United States and Europe. The incidence of pancreatic cancer is rising. Tremendous efforts have been devoted to basic and clinical research in pancreatic cancer. However, the outcome of pancreatic cancer has been minimally improved over the last thirty years. Such a profound sadness tells us that we should spend more efforts and be more focused on this disease. There had been no scientific journal that is solely focused on the malignant diseases of the pancreas. It is critical to have a media to rapidly disseminate research news and reports within the communities of pancreatic cancer researchers and have a venue to discuss the management strategies for pancreatic cancer among clinicians. This is why we are launching Annals of Pancreatic Cancer.

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Original Article

Combination of axial and bivalve techniques in the grossing protocol for pancreaticoduodenectomy specimens in the assessment of ampullary and pancreatic adenocarcinomas and intraductal papillary mucinous neoplasia

Judith González-López, Óscar Castells-Perona, Cecilia López-Valdivia, Roberto Díaz-Beveridge, Cristina Ballester-Ibáñez, Eva Montalvá-Orón, Rafael López-Andújar, Judith Pérez-Rojas

Annals of Pancreatic Cancer

2025;

(30 May 2025)

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Case Report

Clear cell carcinoma of the pancreas: a case report of a not so clear disease

Cassidy Gawlik, Kathryn Stackhouse, Scott E. Kilpatrick

Annals of Pancreatic Cancer

2025;

(30 March 2025)

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Review Article 

Bibliometric review of journal articles on pancreatic cancer: insights into productivity and impact

Christopher Wu, Julia Adriana Kasmirski, Raj Roy, Zhixing Song, Quince-Xhosa D. Gibson, Herbert Chen, J. Bart Rose, Andrea Gillis

Annals of Pancreatic Cancer

2025;

(30 March 2025)

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Original Article

Synthesis and evaluation of novel pyrimidine derivative targeting pancreatic adenocarcinoma

Manjunatha Panduranga Mudgal, Madhu Mallapura Vijayakumar, Ravi Kumar Tiwari, Gurubasavaraja Swamy Purawarga Matada, Suresh Janadri, Uday Raj Sharma

Annals of Pancreatic Cancer

2024;

(31 October 2024)

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Original Article

Diagnostic precision of endoscopic ultrasound versus contrast-enhanced computed tomography in detection of vascular involvement in pancreatic and periampullary cancers as compared to surgery

Amr Abou-Elmagd, Mohamed Yousry Taher, Ahmed Zeid, Ahmed El-Gendi, Ahmed Sedky, Sameh Aldesoky Lashen

Annals of Pancreatic Cancer

2024;

(31 October 2024)

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Case Report

Visceral crisis in a patient with pancreatic ductal adenocarcinoma with DPYD and UGT1A1 gene mutations: case report, literature review, and viewpoint

Luxi Chen, Cynthia Mark, Matthew I. Ebia, Anser Abbas, David Oveisi, Suzanne Dotson, Jun Gong, Andrew Hendifar, Arsen Osipov

Annals of Pancreatic Cancer

2024;

(31 October 2024)

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Original Article

Effects of treatment delays on outcomes in pancreatic adenocarcinoma

Calvin X. Geng, Anuragh R. Gudur, Laura B. Lavette, Ross C. D. Buerlein, Daniel S. Strand, Vanessa M. Shami, Andrew Y. Wang, Matthew J. Reilley, Alexander Podboy

Annals of Pancreatic Cancer

2024;

(30 September 2024)

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Original Article

Probabilistic modelling of pancreatic cancer survival: can Markov chains predict survival in stage IV pancreatic cancer?

Josie Currie, Geoffrey Currie, Eric Rohren

Annals of Pancreatic Cancer

2024;

(31 August 2024)

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Original Article

The impact of KRAS mutations on the clinical outcome and immune response following immunotherapy for pancreatic cancer

Eric S. Christenson, Raymond Yu, Jessica Gai, Hao Wang, Ming Lei, Lei Zheng

Annals of Pancreatic Cancer

2024;

(30 June 2024)

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Case Report

Resolution of a rare case of hypercalcemia in a PTHrp-producing pancreatic neuroendocrine tumor using selective internal radiation therapy with ⁹⁰Y microspheres

Elena Dobra Neacsu, Elena Martínez Montalbán, Bárbara Martínez de Miguel

Annals of Pancreatic Cancer

2024;

(30 June 2024)

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Review Article 

Role of neoadjuvant therapy in resectable pancreatic carcinoma: a review article

Sandeep Purohit, Parveen Ahlawat, Sarthak Tandon, Akash Raghavan Bellige, Munish Gairola

Annals of Pancreatic Cancer

2024;

(30 May 2024)

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Review Article 

Emerging potential value of long non-coding RNAs as biomarkers and therapeutic targets in pancreatic cancer

Zahra Haghshenas, Fatemeh Shaban, Gordon A. Ferns, Elham Nazari

Annals of Pancreatic Cancer

2024;

(30 April 2024)

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Original Article

Quantitative assessment of pancreatic exocrine function in symptomatic patients with locally advanced pancreatic cancer receiving radiation therapy

Yukihiro Hama, Etsuko Tate

Annals of Pancreatic Cancer

2024;

(30 April 2024)

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Original Article

Causal relationship between gut microbiota and pancreatic cancer: a two-sample Mendelian randomisation study

Chongfeng Zhou, Xinjian Xu

Annals of Pancreatic Cancer

2024;

(30 April 2024)

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Case Report

Pancreatic cancer with leptomeningeal carcinomatosis: case report and review of the literature

Michelle Seu, Adriana Sofia P. Perilla, Edward Melian, Michael J. Schneck

Annals of Pancreatic Cancer

2023;

(20 December 2023)

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Review Article 

Contribution of heterogeneity of cancer associated fibroblasts to organ-specific metastasis of pancreatic cancer: will it change the paradigm of treating metastatic pancreatic cancer?

Xiaonan Gong, Tengyi Zhang, Shu Zheng

Annals of Pancreatic Cancer

2023;

(20 November 2023)

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Original Article

Genetic alterations in the neuronal development genes are associated with changes of the tumor immune microenvironment in pancreatic cancer

Kaiyi Mu, Juan Fu, Jessica Gai, Harshitha Ravichandran, Lei Zheng, Wei-Chih Sun

Annals of Pancreatic Cancer

2023;

(20 November 2023)

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Original Article

Modified FOLFIRINOX as the first-line chemotherapy in unresectable and metastatic pancreatic adenocarcinoma—a single-center experience in India

Satyajeet Soni, Arpit Jain, Varun Goyal, Satya Narayan, Pallavi Redhu, Pankaj Goyal, Shiva Shankara Swamy, Vineet Talwar

Annals of Pancreatic Cancer

2023;

(15 November 2023)

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Case Report

Painful tongue lesion as an initial presentation of metastatic pancreatic ductal adenocarcinoma: a case report and review of the literature

Cynthia Mark, Angela Minasyan, Matthew I. Ebia, Anser Abbas, Ankona Ghosh, Rabindra Watson, Horacio M. Maluf, Behrooz Hakimian, Brent Larson, Laura Elizabeth Mcvay, Jun Gong, Andrew Hendifar, Arsen Osipov

Annals of Pancreatic Cancer

2023;

(02 November 2023)

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Case Report

Paraneoplastic Cushing syndrome caused by a pancreatic neuroendocrine tumor: a case report

Faten Cherchir, Sawsen Essayeh, Sabrine Mekni, Wafa Ben Hilel, Faten Gargouri, Karima Khiari, Ibtissam Ben Nacef, Imène Rojbi

Annals of Pancreatic Cancer

2023;

(30 October 2023)

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Abstract

AB091. P063. Case report: stage 4 pancreatic cancer to remission using paricalcitol and hydroxychloroquine in addition to traditional chemotherapy

Stephen Bigelsen

Published online: 23 April 2018

PDF ABSTRACT (16190) Open Access

Review Article 

Preclinical mouse models for immunotherapeutic and non-immunotherapeutic drug development for pancreatic ductal adenocarcinoma

Mengni He, MacKenzie Henderson, Stephen Muth, Adrian Murphy, Lei Zheng

Published online: 22 July 2020

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Foreword

Introduction of special column “Case Report/Precision Medicine”

Xu Che, Lei Zheng

Published online: 25 August 2020

PDF Pages: 11 Full Text (10099) COI Form Open Access

Review Article 

Multifunctional role of pancreatic stellate cells in pancreatic cancer

Alpha R. Mekapogu, Srinivasa P. Pothula, Romano C. Pirola, Jeremy S. Wilson, Minoti V. Apte

Published online: 12 June 2019

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Original Article

Modified FOLFIRINOX as the first-line chemotherapy in unresectable and metastatic pancreatic adenocarcinoma—a single-center experience in India

Satyajeet Soni, Arpit Jain, Varun Goyal, Satya Narayan, Pallavi Redhu, Pankaj Goyal, Shiva Shankara Swamy, Vineet Talwar

Published online: 15 November 2023

PDF Full Text (9155) Data Sharing Statement Peer Review File COI Form Open Access

Review Article 

Genetics and biology of pancreatic cancer and its precursor lesions: lessons learned from human pathology and mouse models

Motoyuki Tsuda, Akihisa Fukuda, Kyoichi Takaori, Hiroshi Seno

Published online: 22 August 2019

PDF Full Text (8988) COI Form Open Access

Review Article 

Cellular crosstalk mediating immune evasion in pancreatic cancer microenvironment

Chenggang Gao, Qiang Shen, Tao Yin

Published online: 19 July 2019

PDF Full Text (8123) COI Form Open Access

Review Article 

Ductal vs. acinar? Recent insights into identifying cell lineage of pancreatic ductal adenocarcinoma

Yi Xu, Jun Liu, Michael Nipper, Pei Wang

Published online: 17 June 2019

PDF Full Text (7902) COI Form Open Access

Review Article 

Superior mesenteric artery-first approach with laparoscopic pancreaticoduodenectomy

Xu Sun, Jing Mao, Xiaofeng Ni, Qiang Yan

Published online: 19 August 2019

PDF Full Text (7490) COI Form Open Access

Review Article 

Malnutrition, frailty, and sarcopenia in pancreatic cancer patients: assessments and interventions for the pancreatic surgeon

Noah S. Rozich, Caitlin E. Jones, Katherine T. Morris

Published online: 11 March 2019

PDF Full Text (6645) COI Form Open Access

Review Article 

Targeting the epigenome of pancreatic cancer for therapy: challenges and opportunities

Marina Baretti, Nita Ahuja, Nilofer Saba Azad

Published online: 23 October 2019

PDF Full Text (6623) COI Form Open Access

Review Article 

Adjuvant therapeutic strategies for resectable pancreatic adenocarcinoma

Nikhil Yegya-Raman, Mihir M. Shah, Miral S. Grandhi, Elizabeth Poplin, David A. August, Timothy J. Kennedy, Usha Malhotra, Kristen R. Spencer, Darren R. Carpizo, Salma K. Jabbour

Published online: 07 August 2018

PDF Full Text (6531) COI Form Open Access

Review Article 

Altering the response to radiation: radiosensitizers and targeted therapies in pancreatic ductal adenocarcinoma: preclinical and emerging clinical evidence

Adam R. Wolfe, Terence M. Williams

Published online: 31 August 2018

PDF Full Text (6496) COI Form Open Access

Review Article 

Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors

Jessica L. Buicko, Brendan M. Finnerty, Tiantian Zhang, Bu Jung Kim, Thomas J. Fahey III, Yi-Chieh Nancy Du

Published online: 20 June 2019

PDF Full Text (6396) COI Form Open Access

Review Article 

Modeling human pancreatic ductal adenocarcinoma for translational research: current options, challenges, and prospective directions

Reecha Suri, Jacquelyn W. Zimmerman, Richard A. Burkhart

Published online: 29 December 2020

PDF Full Text (6200) COI Form Open Access

Review Article 

The present and future of systemic and microenvironment-targeted therapy for pancreatic adenocarcinoma

Arnav Mehta, William L. Hwang, Colin Weekes

Published online: 20 May 2020

PDF Pages: 3 Full Text (6015) COI Form Open Access

Original Article

Effects of treatment delays on outcomes in pancreatic adenocarcinoma

Calvin X. Geng, Anuragh R. Gudur, Laura B. Lavette, Ross C. D. Buerlein, Daniel S. Strand, Vanessa M. Shami, Andrew Y. Wang, Matthew J. Reilley, Alexander Podboy

Published online: 20 September 2024

PDF Full Text (6049) Peer Review File COI Form Open Access

Case Report

Resolution of a rare case of hypercalcemia in a PTHrp-producing pancreatic neuroendocrine tumor using selective internal radiation therapy with ⁹⁰Y microspheres

Elena Dobra Neacsu, Elena Martínez Montalbán, Bárbara Martínez de Miguel

Published online: 13 June 2024

PDF Full Text (5957) Peer Review File COI Form Open Access

Original Article

Probabilistic modelling of pancreatic cancer survival: can Markov chains predict survival in stage IV pancreatic cancer?

Josie Currie, Geoffrey Currie, Eric Rohren

Published online: 05 August 2024

PDF Full Text (5874) Data Sharing Statement Peer Review File COI Form Open Access

Original Article

Diagnostic precision of endoscopic ultrasound versus contrast-enhanced computed tomography in detection of vascular involvement in pancreatic and periampullary cancers as compared to surgery

Amr Abou-Elmagd, Mohamed Yousry Taher, Ahmed Zeid, Ahmed El-Gendi, Ahmed Sedky, Sameh Aldesoky Lashen

Published online: 10 October 2024

PDF Full Text (5627) Data Sharing Statement Peer Review File COI Form Open Access

Full Most Read article list >>

Original Article

Quantitative metric for assessment of pancreatic ductal adenocarcinoma treatment response in T1-weighted gadolinium-enhanced magnetic resonance imaging

Joy Liau, Srinivasan Vedantham, Hani M. Babiker, Travis McGlothin, Diego R. Martin

Original Article

Nonselective β-adrenergic blockade impacts pancreatic cancer tumor biology, decreases perineural invasion and improves patient survival

Alex B. Blair, Noelle R. Jurcak, Ammar Javed, Jonathan Teinor, Vincent P. Groot, Noah Rozich, John L. Cameron, Matthew J. Weiss, Jin He, Christopher L. Wolfgang, Lei Zheng, Richard A. Burkhart

Original Article

Analyzing outcomes of neoadjuvant and adjuvant treatment for borderline-resectable pancreatic adenocarcinoma in the perioperative period at an academic institution

Alejandro Recio-Boiles, Jessica Vondrak, Summana Veeravelli, James J. Mancuso, Kathylynn Saboda, Denise J. Roe, Irbaz Bin Riaz, Aaron J. Scott, Emad Elquza, Ali McBride, Hani M. Babiker

Original Article

Adding combination immunotherapy consisting of cancer vaccine, anti-PD-1 and anti-CSF1R antibodies to gemcitabine improves anti-tumor efficacy in murine model of pancreatic ductal adenocarcinoma

May Tun Saung, Lei Zheng

Original Article

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios inversely correlate to clinical and pathologic stage in patients with resectable pancreatic ductal adenocarcinoma

Alejandro Recio-Boiles, Aparna Nallagangula, Summana Veeravelli, Jessica Vondrak, Kathylynn Saboda, Denise Roe, Emad Elquza, Ali McBride, Hani M. Babiker

Review Article 

Modeling human pancreatic ductal adenocarcinoma for translational research: current options, challenges, and prospective directions

Reecha Suri, Jacquelyn W. Zimmerman, Richard A. Burkhart

Review Article 

Preclinical mouse models for immunotherapeutic and non-immunotherapeutic drug development for pancreatic ductal adenocarcinoma

Mengni He, MacKenzie Henderson, Stephen Muth, Adrian Murphy, Lei Zheng

Review Article 

Targeting homologous recombination addicted tumors: challenges and opportunities

Talia Golan, Jonathan R. Brody

Review Article 

Evolving trends in pancreatic cancer therapeutic development

Imani Bijou, Jin Wang

Review Article 

Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors

Jessica L. Buicko, Brendan M. Finnerty, Tiantian Zhang, Bu Jung Kim, Thomas J. Fahey III, Yi-Chieh Nancy Du

Review Article 

Ductal vs. acinar? Recent insights into identifying cell lineage of pancreatic ductal adenocarcinoma

Yi Xu, Jun Liu, Michael Nipper, Pei Wang

Review Article 

Malnutrition, frailty, and sarcopenia in pancreatic cancer patients: assessments and interventions for the pancreatic surgeon

Noah S. Rozich, Caitlin E. Jones, Katherine T. Morris

Review Article 

Altering the response to radiation: radiosensitizers and targeted therapies in pancreatic ductal adenocarcinoma: preclinical and emerging clinical evidence

Adam R. Wolfe, Terence M. Williams

Review Article 

Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy

Sweet Ping Ng, Eugene J. Koay

Review Article 

Adjuvant therapeutic strategies for resectable pancreatic adenocarcinoma

Nikhil Yegya-Raman, Mihir M. Shah, Miral S. Grandhi, Elizabeth Poplin, David A. August, Timothy J. Kennedy, Usha Malhotra, Kristen R. Spencer, Darren R. Carpizo, Salma K. Jabbour

Review Article 

Robotic distal pancreatectomy: greatest benefit for the frail?

Ioannis T. Konstantinidis, Laleh G. Melstrom

Editorial

Stressing for sugar: a new role of serotonin for glycolysis in pancreatic cancer cells

Gregory B. Lesinski

Editorial

Can computational modeling help in personalizing the care of patients with pancreatic ductal adenocarcinoma?

Efrat Dotan

Perspective 

Immune defects in pancreatic cancer

Lei Zheng

Journal Highlight more

Annals of Pancreatic Cancer is an international, open access, peer-reviewed journal for all researchers in the field of pancreatic cancer and for all health care providers who manage the care of pancreatic cancer patients, covering areas of basic biology and immunology, epidemiology, prevention, diagnosis, treatment, and supportive care.